LUP publications 2008
Search 17 grants MYELIN is the most stable membrane known and the fact that it contains ten times as much long chain sphingolipid as any other known membrane structure has led to the suggestion that the long chain fatty acids (> 18 carbon atoms) in these sphingolipids are concerned in the stability of myelin1,2. The finding3,4 of a myelin deficient mouse mutant whose galactolipids and Despite the extraordinary abundance of 2-OH galactolipids in myelin, there is surprisingly little understanding of the basic biochemistry and physiological role of 2-OH galactolipids. The overall goal of this study is to elucidate the pathway for myelin 2-OH lipids and their roles in myelination, myelin function, and cell signaling. Abstract: The developmental lipid profiles in the human cerebrum, cerebellum and brain stem are presented, with special reference to galactolipids as myelin markers to trace myelination in the three main parts of the human CNS. A group of undernourished children were also studied to test the vulnerability of myelinogenesis in the different regions of the human brain. Myelination was well 2013-08-30 · Introduction.
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PY - 2014. Y1 - 2014. N2 - Myelin membrane biogenesis and maintenance require a tight regulation of complex intracellular trafficking machineries, involving appropriate and sequential transportation of major myelin lipids and proteins to their final destination, where they can exert their function. The precise alignment of myelin segments along the length of the axon is essential for the saltatory propagation of an electrical impulse. Furthermore, node of Ranvier formation and function are depe The myelin membrane is unique in that 70% of its dry weight consists of lipids, including cholesterol and galactolipids in particular, and it contains a specific set of proteins including proteolipid protein (PLP) and myelin basic protein (MBP).
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Myelination was well 2013-08-30 · Introduction. Galactolipids are glycoglycerolipids with galactose(s) at the sn-3 position of sn-1,2-diacylglycerol (DAG; Figure 1; Nakamura et al., 2010).Plant photosynthetic membranes are unique in using galactolipids as a major constituent of biological membranes instead of phospholipids, which most other organisms use. The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C. de Jonge , Don C. Lamb, Dick Hoekstra , Nicoletta Kahya * , Wia Baron Se hela listan på frontiersin.org In conclusion, the long chain fatty acids of galactolipids and sphingomyelin are considerably diminished in the “Quaking” mouse. Whether it is a cause or a consequence of myelination defi- ciency remains to be proved, although the importance of the alteration is in favour of the first hypothesis.
Medical Subject Headings - MeSH - ONKI3
accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE.
Whether it is a cause or a consequence of myelination defi- ciency remains to be proved, although the importance of the alteration is in favour of the first hypothesis. Sidman et al. Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty acids. We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain.
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AU - Ozgen, Hande. PY - 2014.
We recently reported that fatty acid 2-hydroxylase (FA2H), encoded by the FA2H gene, is the major fatty acid 2-hydroxylase in the mouse brain. In this report, we show that FA2H also plays a major role in the formation of 2-hydroxy
The role of gangliosides in myelination is mainly associated with their ability to establish and modulate glia axon connections and MAG‐ganglioside downstream signalling (Schmitt et al., 2015). On the contrary of gangliosides, galactolipids, that is GalCer and sulphatides with long fatty acid chains (24:0 and 24:1), are abundant components of the myelin sheath. 2002-08-01
Because of their early appearance and abundant expression, the roles the galactolipids play during the myelination process has been the subject of numerous studies (reviewed in Dupree et al., 1998a).
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LUP publications 2008
Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C. de Jonge, Don C. Lamb, Dick Hoekstra, Nicoletta Kahya *, Wia Baron 1970-08-01 The fatty acid compositions of galactolipids in neonatal mouse brain gradually changed during the course of myelination. The relative ratio of 2-hydroxy versus nonhydroxy galactolipids was very low at 2 days of age (∼8% of total galactolipids) and increased 6- to 8-fold by 30 days of age.
LUP publications 2008
Moreover, at T. Coetzee et al.– Myelin galactolipids REVIEW Fig. 1. Despite the extraordinary abundance of 2-OH galactolipids in myelin, there is surprisingly little understanding of the basic biochemistry and physiological role of 2-OH galactolipids. The overall goal of this study is to elucidate the pathway for myelin 2-OH lipids and their roles in myelination, myelin function, and cell signaling. 2013-08-30 CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): We have analyzed mice that lack both the myelinassociated glycoprotein (MAG) and the myelin galactolipids, two glial components implicated in mediating axo-glial interactions during the myelination process. The single-mutant mice produce abnormal myelin containing similar ultrastructural abnormalities, suggesting that Epigenetic control of Myelination in PNS Review Review Molecular mechanisms regulating myelination in the peripheral nervous system Jorge A. Pereira, Fre´de´ric Lebrun-Julien and Ueli Suter Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Zu¨ rich, CH-8093 Zu¨ rich, Switzerland Glial cells and neurons are engaged in a continuous and highly Astrocytes, Implications for Myelination and Remyelination Veronica T. Cheli1, J. Correale2, Pablo M. Paez1 and Juana M. Pasquini3 Abstract Iron is a key nutrient for normal central nervous system (CNS) development and function; thus, iron deficiency as well as iron … The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near normal compaction.
"Galactolipids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings).Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity. Abstract Myelin in the mammalian nervous system has a high concentration of galactolipids [galactosylceramide (GalCer) and sulfatide] with 2-hydroxy fatty glycosphingolipids; myelination; mouse mutant; maturation. ABSTRACT which are incapable of synthesizing the myelin galactolipids, here we show that there. A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation.